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It has been suggested that aspirin like cortisone inhibits inflammatory reaction in rats. Lysosomal membrane stability is proposed as a mechanism of antiinflammatory reaction of aspirin. This experimental study was designed to observe the effect of aspirin on inflammatory reaction of the skin in the rat. Rats are divided into 3 groups, namely control, SA Ⅰ, and SA Ⅱ. In the control group, skin incision was made then sutured on the abdominal wall after clipping of hair under anesthesia. In the SA Ⅰ group, aspirin 150㎎/㎏ was given one day before wounding. In the SA Ⅱ group, aspirin 150㎎/㎏ of aspirin was given immediately after surgical procedure. Rats are sacrificed under the scheduled time table of 6, 12 hours, 1,2,3,4,5,6,10, and 14 days after wounding, then histo-pathologic studies were carried out on the wounded skin. Obtained results were as follows: 1. SA Ⅰ and SA Ⅱ group showed obviously reduced neutrophilic leukocyte infiltration and suppressed vascular reaction in the eary stage of inflammatory process. 2. Fibroblast proliferation as well as collagen fiber formation are delayed in the repair process in the group SA Ⅰ and SA Ⅱ. 3. Inflammatory reaction and repair proces are more suppressed in the SA Ⅱ group than SA Ⅰ group. 4. The above changes suggests that anti-inflammatory reaction of aspirin is due to suppression of cell infiltration in the early stage of inflammatory reaction.
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